Production of no-carrier-added Ho-166 for targeted therapy purposes

نویسندگان

  • Ali Bahrami-Samani Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
  • Amir Reza Jalilian Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran|Radioisotope Products and Radiation Technology Section, Department of Nuclear Sciences and Applications, International Atomic Energy Agency (IAEA), Vienna, Austria
  • Nafiseh Salek Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
  • Sara Vosoughi Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
چکیده مقاله:

Introduction:Holmium-166 radionuclide is one of the most effective radionuclides used for targeted therapy with theranostic properties. One method to produce this radioisotope is via the decay of its parent (indirect method). In this study applicability of extraction chromatography (EXC) for separation of no carrier added 166Ho from neutron-irradiated natural dysprosium target followed by quality control procedures have been demonstrated. Methods: 166Dy was produced by thermal neutron bombardment (5×1013n/cm2.s) of natural 164Dy target through 164Dy (n,γ) 165Dy (n,γ) 166Dy process in a nuclear reactor. The generator-produced 166Ho was separated from 166Dy by extraction chromatographic method. The extractant used in resin was 2-ethylhexyl 2-ethylhexylphosphonic acid (HEH[EHP]). The final solution went through radionuclide, chemical and radiochemical purity tests. Results: Using 1.5 M HNO3 as eluent at 25 °C, and flow rate of 1.5 mL/min, quantitative separation between Ho and Dy was achieved using LN2 resin in 1.5 h to yield in no carrier added 166HoCl3 (radionuclide purity >99.9%; separation yield; 76% and radiochemical purity >99% ITLC). Conclusion: High specific activity 166HoCl3 produced in this study is highly suitable for metal sensitive labeling of monoclonal antibodies, fragments and especially peptides to yield efficient therapeutic doses for human applications.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

production of no-carrier-added ho-166 for targeted therapy purposes

introduction:holmium-166 radionuclide is one of the most effective radionuclides used for targeted therapy with theranostic properties. one method to produce this radioisotope is via the decay of its parent (indirect method). in this study applicability of extraction chromatography (exc) for separation of no carrier added 166ho from neutron-irradiated natural dysprosium target followed by quali...

متن کامل

Targetry for cyclotron production of no-carrier-added cadmium-109 from natAg(p,n)109Cd reaction

Background: Solid targets that consist of powder and electrodeposited targets are used commonly to produce radionuclides by accelerators. Since silver is easily electrodeposited in cyanide baths and has a very excellent thermal conductivity, the electrodeposited target is preferable to produce 109Cd. To avoid cracking or peeling of the target during bombardment, it should have a level surface a...

متن کامل

targetry for cyclotron production of no-carrier-added cadmium-109 from natag(p,n)109cd reaction

background: solid targets that consist of powder and electrodeposited targets are used commonly to produce radionuclides by accelerators. since silver is easily electrodeposited in cyanide baths and has a very excellent thermal conductivity, the electrodeposited target is preferable to produce 109cd. to avoid cracking or peeling of the target during bombardment, it should have a level surface a...

متن کامل

Cyclotron production of no-carrier-added palladium-103 by bombardment of rhodium-103 target.

Electroplated rhodium foil was employed as the target for cyclotron production of palladium-103. An electrodissolution apparatus was found better than other dissolution methods in terms of personnel shielding and palladium-103 yield. The ion-exchange column chromatography method was simple and effective for the purification of palladium-103 and the final stripping agent of NH4Cl + NH3(1:1) was ...

متن کامل

Cyclotron Production of “very High Specific Activity” Platinum Radiotracers in No Carrier Added Form*

At the "Radiochemistry Laboratory" of Accelerators and Applied Superconductivity Laboratory, LASA, several production and quality assurance methods for short-lived and high specific activity radionuclides, have been developed. Presently, the irradiations are carried out at the Scanditronix MC40 cyclotron (K=38; p, d, He-4 and He3) of JRC-Ispra, Italy, of the European Community, while both chemi...

متن کامل

Production at the Curie level of no-carrier-added 6-18F-fluoro-L-dopa.

UNLABELLED 6-(18)F-fluoro-L-dopa ((18)F-FDOPA) has proven to be a useful radiopharmaceutical for the evaluation of presynaptic dopaminergic function using PET. In comparison to electrophilic synthesis, the no-carrier-added (NCA) nucleophilic method has several advantages. These include much higher available activity and specific activity. Recently, we have described an NCA enantioselective synt...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 25  شماره Supplement 1

صفحات  15- 20

تاریخ انتشار 2017-02-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023